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Contraindicated (1)pentobarbital will lower the level or result of cariprazine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is to blame for the development and elimination of cariprazine's Lively metabolites.Pentobarbital also is effective by inhibiting glutamate, which is answerable for nerve depolarization whi